Abstract: The determination of wire rope’s fixation mode of ultra-deep winding mine hoist plays an indispensable role in the safe and reliable operation of the shaft hoist spindle and its system. Aiming at the problem that rope’ s fixation mode has an effect on the bearing capacity of spindle,the comprehensive research methods of mechanics model have been established,numerical simulation and finite element analysis have been used to derive the general formula of the variable load of the spindle,16 kinds of working conditions have been programmed and the simulation analysis has been carried out,and then the best fixation mode of wire rope is proposed by comparison. Research shows that the gen- eral formula proposed is suitable for the left and right drum under 16 kinds of working conditions when lifting or lower- ing. The selection of S-curve speed or multi-stage speed operation benefits the stability of spindle. The best fixation mode is lower left fixation for mobile drum’s double-rope area and upper right fixation for fixed drum’ s double-rope area when the web is symmetrical or asymmetrical (difference of L8 ,L10 within 150 mm). Research methods and results will benefit the instantaneous load of spindle, and offer theoretical references to design spindle and determine the rope’ fixation mode of ultra-deep mine hoist.