Abstract: The occurrence and output of coalbed methane (CBM) are controlled by the occurrence geological conditions of coal reservoirs, such as stress, pressure, and temperature. The correct analysis of the occurrence geological conditions of coal reservoirs and their impact on permeability is a key issue of concern for an effective development of CBM. Based on the test data of 63 CBM wells in the southern part of the Qinshui Basin, the ground stress, pressure and temperature conditions of coal reservoirs in the study area are systematically analyzed, the variation law of coal reservoir stress, pressure and temperature with burial depth is revealed, and the relationship between the minimum horizontal principal stress and the vertical principal stress and the pressure of coal reservoir is established. Using the triaxial seepage test system, the experiment of CBM seepage under different stress, pressure and temperature conditions is carried out, and the variation law and control mechanism of coal sample permeability under different temperature, stress and pressure conditions are revealed. The results show that the maximum and minimum horizontal principal stresses of the coal reservoirs in the study area are 6.62−42.06 MPa and 3.30−26.40 MPa, respectively, with the gradients of 1.20−5.26 MPa/hm and 0.99−2.95 MPa/hm, respectively. The coal reservoir pressures and their gradients are 0.99−12.63 MPa and 0.23−1.18 MPa/hm; the coal reservoir temperatures and their gradients are 19.36−38.84 ℃ and 1.98 ℃/hm, respectively. The coal reservoir stress, pressure and temperature increase linearly with the increase of depth. With the increase of effective stress, the permeability of the coal reservoir decreases continuously, the permeability decreases greatly in the initial pressurization stage, but decrease slows down with the increase of effective stress. Under the same stress conditions, the permeability of coal samples and the decrease rate of permeability decrease continuously with the increase of temperature. With the increase of effective stress and temperature, the permeability of coal reservoir decreases according to the law of negative exponential function. With the decrease of pore pressure, the effective stress increases, but the permeability of coal reservoir decreases. In the initial depressurization stage, the permeability of the coal reservoir decreases sharply, and with the reduction of pore pressure, the decrease rate of permeability gradually slows down. When the pore pressure is less than 0.6 MPa, the permeability of the coal reservoir increases with the decrease of pore pressure. Under the condition of high pore pressure, the permeability decreases with the increase of temperature in a negative exponential function, while under the condition of low pore pressure, the permeability of coal reservoir decreases linearly with the increase of temperature. Based on the above results, the relationship model between coal reservoir permeability and stress, pressure and temperature is established. Also, the law and control mechanism of coal reservoir permeability decrease according to negative exponential function with the increase of stress, pressure and temperature stress are expounded.